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Clomipramine

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HOME >> API >> API List1 >> Clomipramine HCL >> Side Effects

Formula C19H23ClN2


SIDE EFFECTS
Clomipramine CAS number 17321-77-6

The most commonly observed adverse events associated with the use of clomipramine and not seen at an equivalent incidence among placebo-treated patients were gastrointestinal complaints, including dry mouth, constipation, nausea, dyspepsia, and anorexia; nervous system complaints, including somnolence, tremor, dizziness, nervousness and myoclonus; genitourinary complaints including changed libido, ejaculatory failure, impotence and micturition disorder; and other miscellaneous complaints, including fatigue, sweating, increased appetite, weight gain, and visual changes.

The tabulations that follow list adverse reactions that have also been observed with clomipramine; these are categorized by organ system and listed in order of decreasing frequency.

Neurological:
Extrapyramidal effects such as ataxia, also headache, delirium, speech disorders, muscle weakness, muscle hypertonia, tinnitus, paresthesias of the extremities, convulsions, EEG changes, hyperpyrexia. Peripheral neuropathy has been reported with other tricyclic antidepressants.

Behavioral:
Drowsiness, fatigue, restlessness, confusion accompanied by disorientation (particularly in geriatric patients and patients suffering from Parkinson's disease), anxiety states, agitation, sleep disturbances, insomnia, nightmares, aggravated depression, hypomania or manic episodes, disturbed concentration, visual hallucinations, impaired memory, aggressiveness, yawning, depersonalization, activation of latent psychosis, delusions.

Autonomic:
Difficulty with accommodation, slurred speech, urinary retention, hot flushes, mydriasis, glaucoma, paralytic ileus.

Cardiovascular:
Hypotension, particularly orthostatic hypotension with associated vertigo, sinus tachycardia, palpitations. A quinidine-like effect and other reversible ECG changes in patients with normal cardiac status (such as flattening or inversion of T-waves, depressed S-T segments). Arrhythmias, hypertension, conduction disorders (e.g. widening of QRS complex, PQ changes, bundle-branch block), syncope.

Fibrillation, myocardial infarction, stroke and unexpected death in patients with cardiovascular disorders have been reported with tricyclic antidepressants.

Hematologic:
Leukopenia, agranulocytosis, thrombocytopenia, eosinophilia and purpura. One case of pancytopenia has been reported.

Gastrointestinal:
Vomiting, abdominal pain, diarrhea, taste perversion, elevated transaminases, obstructive jaundice, hepatitis with or without jaundice.

Endocrine:
Weight loss, breast enlargement and galactorrhea in the female, inappropriate antidiuretic hormone (ADH) secretion syndrome, gynecomastia in the male, changes in blood sugar levels, increase in prolactin levels, menstrual irregularity.

Allergic or Toxic:
Allergic skin reactions (skin rash, urticaria), photosensitization, pruritus, edema, drug fever.

Withdrawal Symptoms:
Abrupt cessation of treatment with tricyclic antidepressants after prolonged administration may occasionally

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