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CAS Number 107007-99-8

Granisetron Hcl CAS Number 107007-99-8

CYP-450 enzymes

Granisetron does not induce or inhibit the CYP-450 system; however, it is metabolized partially by CYP-450 3A enzymes. Medications that induce or inhibit CYP-450 3A isoenzymes may alter granisetron metabolism.

 * Granisetron was delivered in therapeutic doses over the entire experiment period (”active” curve).
* ViaDerm delivery resulted in a concentration increase of up to 12 hours, and then a constant level of up to 24 hours, relative to peak and valley profiles for oral and IV, and low plasma levels in the control group.
* MicroChannels remained open and enabled drug delivery for at least 24 hours, after which the patches were removed.
* The test subjects reported no pain during or after the ViaDerm treatment or while the Granisetron patch was applied on their skin.
* No irritation was detected following the removal of the patch.

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