Hepatocellular neoplasms and peliosis hepatis have
been reported in association with long-term androgenic anabolic
In men. a. Prepubertal: Phallic enlargement and increased frequency
of erections. b. Postpubertal: Inhibition of testicular function,
testicular atrophy and oligospermia, impotence, chronic priapism,
epididymitis and bladder irritability.
In women: Clitoral enlargement, menstrual irregularities.
In both sexes: Bncreased or decreased libido.
Habituation, excitation, insomnia, depression.
Nausea, vomiting, diarrhea.
Bleeding in patients on concomitant anticoagulant
Deepening of the voice in women.
Hirsutism and male pattern of baldness in women.
Acne (especially in women and prepubertal boys.)
Premature closure of epiphyses in children.
Fluid and Electrolytes:
Edema, retention of serum electrolytes (sodium,
chloride, potassium, phosphate, calcium).
Decreased glucose tolerance, increased serum levels
of low-density lipoprotein and decreased levels of high-density
lipoprotein increased creatine and creatinine excretion,
increased serum levels of creatinine phosphokinase (CPK). Some
virilizing changes in women are irreversible even after prompt
discontinuance of therapy and are not prevented by concomitant use