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Noscapine base tablets

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HOME >> API >> API List 4 >> Noscapine Base >> Drug Description

Noscapine base

DRUG DESCRIPTION
Noscapine base
CAS Number 128-62-1

Noscapine (also known as Narcotine, Nectodon, Nospen, and Anarcotine) is a benzylisoquinoline alkaloid from plants of the Papaveraceae family, without significant painkilling properties. This agent is primarily used for its antitussive (cough-suppressing) effects. It has also been shown to have anticancer activityNoscapine's antitussive effects appear to be primarily mediated by its sigma receptor agonist activity. Evidence for this mechanism is suggested by experimental evidence in rats. Pretreatment with rimcazole, a sigma specific antagonist, causes a dose-dependent reduction in antitussive activity of noscapineNoscapine is currently under investigation for use in the treatment of several cancers and hypoxic ischemia in stroke patients. In cancer treatment, noscapine appears to interfere with microtubule function, and thus the division of cancer cells in a way similar to the taxanes. Early studies in treatment of prostate cancer are very promising.In stroke patients, noscapine blocks the bradykinine b-2 receptors. A 2003 study in Iran showed a dramatic decrease in mortality in patients treated with noscapine.

An isoquinoline alkaloid, occurring in opium, with papaverinelike action on smooth muscle; suppresses the cough reflex and this is used as an antitussive; it does not appear to cause addiction.

Noscapine has a history of over-the-counter drug abuse in a several countries, being readily available from local pharmacies as a prescription drug. The effects, beginning around 45 to 120 mins after consumption, are similar to dextromethorphan and alcohol intoxication. Abuse of noscapine and other cough suppressants (dextromethorphan, codeine, and antihistamines) has been reported to cause chronic cough lasting over one month upon withdrawal

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