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Ziprasidone-Hcl Taj API

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HOME >> API >> API List 3 >> Ziprasidone Hcl >> Drug Description

Ziprasidone Hcl CAS Registry Number 138982-67-9


Ziprasidone Hcl CAS Registry Number 138982-67-9

Ziprasidone Hcl Capsules contain a monohydrochloride, monohydrate salt of ziprasidone. Chemically, ziprasidone hydrochloride monohydrate is 5-[2-[4-(1,2-benzisothiazol-3-yl)-1-piperazinyl]ethyl]-6-chloro-1,3-dihydro-2H-indol-2-one, monohydrochloride, monohydrate. The empirical formula is C21H21ClN4OS HCl H2O and its molecular weight is 467.42. Ziprasidone hydrochloride monohydrate is a white to slightly pink powder.

Ziprasidone Hcl is available as  Capsules for oral administration and is most effective when taken with food. It has been approved for treatment of schizophrenia.

Ziprasidone Hcl is a serotonin dopamine antagonist that works to treat the positive, negative, and depressive symptoms associated with schizophrenia. Positive symptoms include visual and auditory hallucinations and delusions. Negative symptoms, which are harder to treat, include blunted affect, social withdrawal, and lack of motivation.

Schizophrenia is a chronic illness that requires lifelong treatment.

The efficacy of  Capsules ( hydrochloride) as a treatment for schizophrenia was established in four short-term, four to six week trials and one long-term 52 week trial. All were placebo-controlled studies in inpatients, most of whom met DSM III-R criteria for schizophrenia. Each trial evaluated two or three fixed doses of , ranging from 20 to 100 mg,

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Ziprasidone Hcl

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