|
|
PHARMALOGY
Dobutamine
CAS Number 49745-95-1
Dobutamine is a direct-acting agent whose primary activity results from
stimulation of the β1-adrenoceptors of the heart, increasing contractility
and cardiac output. Since it does not act on dopamine receptors to induce
the release of norepinephrine (another α1 agonist), dobutamine is less prone
to induce hypertension than is dopamine. Arrhythmogenic and vasodilative
effects are negligible.[citation needed]
Dobutamine is predominantly a β1-adrenergic agonist, with weak β2 activity,
and α1 selective activity, although it is used clinically in cases of
cardiogenic shock for its β1 inotropic effect in increasing heart
contractility and cardiac output. Dobutamine is administered as a racemic
mixture consisting of both (+) and (−) isomers, and the (+) isomer is a
potent β1 agonist while the (−) isomer is a α1 agonist. Dobutamine also has
mild β2 agonist activity
 
|
©
2004 - 2009
Taj Pharmaceuticals Limited
. All rights reserved
India