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HOME >> API >> API List 2 >> Letrozole >> Dosage

Letrozole  Molecular Formula C17H11N5

DOSAGE
Letrozole CAS Registry Number 112809-51-5

The recommended dose of ® (letrozole tablets) is one 2.5 mg tablet administered once a day, without regard to meals. In patients with advanced disease, treatment with  should continue until tumor progression is evident.

In the extended adjuvant setting, the optimal treatment duration with  is not known. The planned duration of treatment in the study was 5 years. However, at the time of the analysis, the median treatment duration was 24 months, 25% of patients were treated for at least 3 years and less than 1% of patients were treated for the planned duration of 5 years. The median duration of follow-up was 28 months. Treatment should be discontinued at tumor relapse
In the adjuvant setting, the optimal duration of treatment with letrozole is unknown. The planned duration of treatment in the study is 5 years. However, at the time of analysis, the median duration of treatment was 24 months, median duration of follow-up was 26 months, and 16% of the patients have been treated for 5 yearsNo dose adjustment is required for elderly patients. Patients treated with  do not require glucocorticoid or mineralocorticoid replacement therapy.o dose adjustment is required for elderly patients. Patients treated with  do not require glucocorticoid or mineralocorticoid replacement

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SIDE EFFECTS
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