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DOSAGE
Zonisamide
CAS number 68291-97-4
Zonisamide are recommended as adjunctive therapy for the treatment
of partial seizures in adults. Safety and efficacy in pediatric patients
below the age of 16 have not been established. Zonisamide should be
administered once or twice daily, using 25 mg, 50 mg or 100 mg . Zonisamide
are given orally and can be taken with or without food. should be
swallowed whole.
Adults over Age 16:
The prescriber should be aware that, because of the long half-life of
Zonisamide, up to two weeks may be required to achieve steady state levels
upon reaching a stable dose or following dosage adjustment. Although the
regimen described below is one that has been shown to be tolerated, the
prescriber may wish to prolong the duration of treatment at the lower doses
in order to fully assess the effects of Zonisamide at steady state, noting
that many of the side effects of Zonisamide are more frequent at doses of
300 mg per day and above. Although there is some evidence of greater
response at doses above 100-200 mg/day, the increase appears small and
formal dose-response studies have not been conducted.
Patients with Renal or Hepatic Disease:
Because Zonisamide is metabolized in the liver and excreted by the kidneys,
patients with renal or hepatic disease should be treated with caution, and
might require slower titration and more frequent monitoring.
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