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Primidone
CAS number 125-33-7
Systematic (IUPAC) name
5-ethyl-5-phenyl-hexahydropyrimidine-4,6-dione
Identifiers
CAS number 125-33-7
ATC code N03AA03
PubChem 4909
DrugBank APRD00549
ChemSpider 4740
Chemical data
Formula C12H14N2O2
Mol. mass 218.252 g/mol
Pharmacokinetic data
Bioavailability ~100%
Protein binding 25%
Metabolism Hepatic
Half life Primidone: 5-18 hours,
Phenobarbital: 75-120 hours,
PEMA: 16 hours
Time to reach steady state:
Primidone: 2-3 days,
Phenobarbital&PEMA 1-4weeks
Excretion Renal
Primidone is an anticonvulsant of the pyrimidinedioneclass whose active
metabolites, phenobarbitaland phenylethylmalonamide are also
anticonvulsants. It is used mainly to treat complex partial, simple
partials, generalized tonic-clonic seizures, myoclonic, akinetic seizures
and it has been a valuable alternative to propranolol in the treatment
of essential tremor. Unlike other anticonvulsants such as carbamazepine and
valproic acid, primidone is rarely used in the treatment of bipolar disorder
or any other psychiatric problem. It is also not widely used in treatment of
neuropathic pain, trigeminal neuralgia, or migraine. Primidone has been
occasionally used to treat long QT syndrome, cerebral palsy, and athetosis.
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