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Omeprazole Sodium
CAS number 95510-70-6
omeprazole/sodium bicarbonateis a combination of omeprazole, a
proton-pump inhibitor, and sodium bicarbonate, an antacid. Omeprazole is a
substituted benzimidazole,
5-methoxy-2-[[(4-methoxy-3,5-dimethyl-2-pyridinyl)methyl]sulfinyl]-1H-benzimidazole,
a racemic mixture of two enantiomers that inhibits gastric acid secretion.
Its empirical formula is C17H19N3O3S, with a molecular weight of 345.42.
Omeprazole is a white to off-white crystalline powder which melts with
decomposition at about 155°C. It is a weak base, freely soluble in ethanol
and methanol, and slightly soluble in acetone and isopropanol and very
slightly soluble in water. The stability of omeprazole is a function of pH;
it is rapidly degraded in acid media, but has acceptable stability under
alkaline conditions.
omeprazole is supplied as immediate-release capsules and unit-dose
packets as powder for oral suspension. Each capsule contains either 40 mg or
20 mg of omeprazole and 1100 mg of sodium bicarbonate with the following
excipients: croscarmellose sodium and sodium stearyl fumarate. Packets of
powder for oral suspension contain either 40 mg or 20 mg of omeprazole and
1680 mg of sodium bicarbonate with the following excipients: xylitol,
sucrose, sucralose, xanthan gum, and flavorings.
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