Dextromethorphan Hbr Side Effects
extromethorphan hydrobromide monohydrate occurs as white
crystals, is sparingly soluble in water, and is freely soluble in
alcohol. The empirical formula is C18H25NO•HBr•H2O, and the
molecular weight of the monohydrate is 370.33. Dextromethorphan HBr
monohydrate is dextrorotatory with a specific rotation of +27.6
degrees in water (20 degrees C, sodium D-line).
Dextromethorphan hydrobromide is a salt of the methyl ether of the
dextrorotatory isomer of levorphanol, a narcotic analgesic. It is
chemically designated as 3-methoxy-17-methyl-9α, 13α, 14α- morphinan
hydrobromide monohydrate with the following structural formula.
Dextromethorphan is a synthetically produced substance that is
related to codeine. It has central cough suppressant action but it
does not feature the untoward effects of the opioids: it does not
have analgesic, sedating or constipating effects. Its metabolism is
genetically polymorphous, similar to the codeine metabolism. Since
its metabolites can be traced in urine, dextrometorphan is suitable
as a testing substance for the definition of the respective
phenotype. The pharmacological potential of dextromethorphan does
not appear to be completely exploited yet. According to more recent
studies (performed predominantly on animals), the substance also has
antiepileptic, neuroprotective, and antiparkinsonian properties.
Promethazine HCl occurs as a white to faint yellow, practically
odorless, crystalline powder which slowly oxidizes and turns blue on
prolonged exposure to air. It is freely soluble in water and soluble
Dextromethorphan is rapidly absorbed from the gastrointestinal tract
and exerts its effect in 15 to 30 minutes. The duration of action
after oral administration is approximately three to six hours.
Promethazine is a phenothiazine derivative which differs
structurally from the antipsychotic phenothiazines by the presence
of a branched side chain and no ring substitution. It is thought
that this configuration is responsible for its relative lack (1/10
that of chlorpromazine) of dopamine antagonist properties.
Promethazine is an H1 receptor blocking agent. In addition to its
antihistaminic action, it provides clinically useful sedative and
The drug acts centrally and elevates the threshold for coughing. It
is about equal to codeine in depressing the cough reflex. In
therapeutic dosage dextromethorphan does not inhibit ciliary
Associated with Product :