This medication is used to treat seizure disorder in adults and
children (age 10 years or older). It is also used to prevent
migraine headaches in adults. This medication works by restoring the
balance of certain natural substances (neurotransmitters) in the
OTHER USES : This drug may also be used to treat certain
psychiatric conditions (e.g., manic phase of bipolar disorder,
schizophrenia) in adults.
TSake this medication by mouth once daily or as directed by your doctor.
You may take it with food if stomach upset occurs. Swallow the
tablet whole. Do not crush or chew the tablet, which can destroy the
long action of the drug and increase side effects. Dosage is based
on your weight, medical condition, and response to therapy. Use this
medication regularly in order to get the most benefit from it.
Remember to use it at the same time each day to keep the amount of
medication in your blood constant. If this medication is used for
seizures, do not stop taking it without consulting your doctor. Your
condition may become worse if the drug is suddenly stopped. Your
dose may need to be gradually decreased. Divalproex sodium does not
relieve acute migraine headaches. Take other medications as directed
by your doctor for acute attacks. Inform your doctor if your
condition does not improve.
What should I discuss with my healthcare provider before taking
divalproex sodium ?
In rare cases, divalproex sodium has caused life-threatening
liver failure, especially in children younger than 2 years old.
Children of this age may be at even greater risk for liver problems
if they use more than one seizure medication, if they have a
metabolic disorder, or if they have a brain disease causing mental
impairment (such as Creutzfeldt-Jacob disease, Huntington disease,
multiple sclerosis, or a brain injury or infection). Divalproex
sodium has also caused rare cases of life-threatening pancreatitis
(inflammation of the pancreas). Pancreatitis can come on suddenly
and symptoms may start even after you have been taking divalproex
sodium for several years. Do not take divalproex sodium if you have
liver disease or a urea cycle disorder.
If you have any of these conditions, you may need a dose
adjustment or special tests to safely take divalproex sodium.
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