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DRUG DESCRIPTION
Esomeprazole Magnesium
CAS number 161796-78-7
The active ingredient in esomeprazole magnesium Delayed-Release Capsules
andFor Delayed-Release Oral Suspension is bis(5
methoxy-2-[(S)-[(4-methoxy-3,5-dimethyl-2-pyridinyl)methyl]sulfinyl]-1H-benzimidazole-1yl)
magnesium trihydrate, a compound that inhibits gastric acid secretion.
Esomeprazole is the S-isomer of omeprazole, which is a mixture of the S- and
R- isomers.Its molecular formula is (C17H18N3O3S)2Mg x 3H2O with molecular
weight of 767.2 as a trihydrate and 713.1 on an anhydrous basis.The
magnesium salt is a white to slightly colored crystalline powder.
It contains 3 moles of water of solvation and is slightly soluble in
water.he stability of esomeprazole magnesium is a function of pH; it rapidly
degrades in acidic media, but it has acceptable stability under alkaline
conditions. At pH 6.8 (buffer), the halflife of the magnesium salt is about
19 hours at 25°C and about 8 hours at 37°C.
Esomeprazole Magnesium relieves heartburn and other symptoms caused by
the backflow of stomach acid into the canal to the stomach (the esophagus)—a
condition known as gastroesophageal reflux disease. It is also prescribed to
heal the damage (erosive esophagitis) that reflux disease can cause.
Prescribed in combination with the antibiotics amoxicillin and
clarithromycin, Esomeprazole Magnesium is also used to treat the
infection that causes most duodenal ulcers (ulcers occurring just beyond the
exit from the stomach).
Like its sister drug omeprazole, Esomeprazole Magnesium works by
reducing the production of stomach acid.
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