Cas No 315-37-7
Side Effects of Testosterone Enanthate - for the Consumer
All medicines may cause side effects, but many people
have no, or minor, side effects. Check with your doctor if any of
these most COMMON side effects persist or become bothersome when
using Testosterone Enanthate:
Acne; bitter or strange taste in mouth; change in sex drive;
fatigue; gum or mouth irritation; gum pain; gum tenderness or
swelling; hair loss; headache.
Seek medical attention right away if any of these SEVERE side
effects occur when using
Severe allergic reactions (rash; hives; itching; difficulty
breathing; tightness in the chest; swelling of the mouth, face,
lips, or tongue); breast growth or pain; change in the size or shape
of the testicles; changes in menstrual periods; coughing fit; dark
urine or light-colored bowel movements; depression or mood changes;
dizziness; facial hair growth; gingivitis; interrupted breathing
while sleeping; loss of appetite; nausea; painful or prolonged
erection; shortness of breath; stomach pain; swelling of the ankles
or legs; urination problems; voice changes or hoarseness; weight
gain; yellowing of the skin or eyes.
Testosterone Enanthate Side Effects - for the Professional
Endocrine and Urogenital, Female - The most common side effects
of androgen therapy are amenorrhea and other menstrual
irregularities, inhibition of gonadotropin secretion, and
virilization, including deepening of the voice and clitoral
enlargement. The latter usually is not reversible after androgens
are discontinued. When administered to a pregnant woman, androgens
cause virilization of the external genitalia of the female fetus.
Male - Gynecomastia, and excessive frequency and duration of penile
erections. Oligospermia may occur at high dosages.
Skin and Appendages - Hirsutism, male pattern baldness, and acne.
Fluid and Electrolyte Disturbances - Retention of sodium, chloride,
water, potassium, calcium, and inorganic phosphates.
Gastrointestinal - Nausea, cholestatic jaundice, alterations in
liver function tests; rarely, hepatocellular neoplasms, peliosis
Hematologic - Suppression of clotting factors II, V, VII, and X;
bleeding in patients on concomitant anticoagulant therapy;
Nervous System - Increased or decreased libido, headache, anxiety,
depression, and generalized paresthesia.
Metabolic - Increased serum cholesterol.
Miscellaneous - Rarely, anaphylactoid reactions; inflammation and
pain at injection site.
Side Effects by Body System
Cardiovascular side effects have included hypertension, and edema
with and without congestive heart failure.
Endocrine side effects have included gynecomastia as a frequent and
sometimes persistent side effect. Cautious use is recommended in
patients with existing gynecomastia.
During exogenous administration of androgens, endogenous
testosterone release is inhibited through feedback inhibition of
pituitary luteinizing hormone (LH). Large doses of exogenous
androgens may suppress spermatogenesis through inhibition of
pituitary follicle stimulating hormone (FSH).
Androgens may decrease levels of thyroxin binding globulin resulting
in decreased total T4 serum levels and increased resin uptake of T3
and T4. Free thyroid hormone levels remain unchanged and there is no
clinical evidence of thyroid dysfunction.
Changes in insulin sensitivity or glycemic control may occur in
patients treated with androgens. In diabetic patients, the metabolic
effects of androgens may decrease blood glucose and, therefore,
Virilization of children has been reported due to secondary exposure
to testosterone. Signs and symptoms have included inappropriate
enlargement of the penis or clitoris, premature development of pubic
hair, increased erections and libido, aggressive behavior, and
advanced bone age. In most cases, these signs and symptoms regressed
with removal of the exposure to testosterone. In a few cases,
however, enlarged genitalia did not fully return to age-appropriate
normal size and bone age remained modestly greater than
Renal side effects have included retention of nitrogen, sodium,
potassium, chloride, water and phosphorus, and decreased urinary
excretion of calcium.
Hepatic side effects have included life-threatening peliosis
hepatitis and hepatic abnormalities including hepatic neoplasms and
hepatocellular carcinomas following prolonged therapy with high
doses of androgen. Tumor regression did not occur in all cases
following medication withdrawal.
Cholestatic hepatitis, jaundice, and abnormal liver function tests
have occurred during androgen therapy. Drug-induced jaundice is
usually reversible following drug discontinuation.
Genitourinary side effects following chronic administration and/or
large dosages of testosterone have included oligospermia and
decreased ejaculatory volume. Elderly male patients have experienced
prostatic enlargement resulting in urinary obstruction. Priapism and
excessive stimulation has developed. Other urinary side effects have
included nocturia, urinary hesitancy, urinary incontinence, urinary
retention, urinary urgency, and weak urinary system.
In female patients the use of androgens has resulted in virilization
including deepening voice, hirsutism, acne, clitomegaly (not
reversible), and menstrual abnormalities. Discontinuation of
testosterone at signs of mild virilization may prevent irreversible
Metabolic side effects have included osteolytic-induced
hypercalcemia in immobilized patients or those with metastatic
breast disease. Increased cholesterol levels and acute intermittent
porphyria have been reported.
Other side effects have included virilization in female patients.
Virilization included deepening voice, hirsutism, acne, clitomegaly
(not reversible), and menstrual abnormalities.
Female sexual partners of men using topical testosterone (residual
on skin) have reported virilization.
Dermatologic side effects have included hirsutism, acne,
male-patterned baldness and seborrhea. Dermal reactions have been
the most commonly reported side effects for transdermal testosterone
and occur primarily at the site of application. Dermal effects have
included 3 types: irritation including mild to moderate erythema (to
6%), induration (3%), itching (12%), and burning (3%); allergic
contact dermatitis including pruritus (to 37%), vesicles (6%), and
rash (2%); and burn-like blisters (12%).
Discontinuation rates for transdermal testosterone were as follows:
due to chronic skin irritation (5%), allergic dermal reactions (4%),
and burn-like, usually a single site (0%).
Triamcinolone 1% cream applied sparingly to skin under the reservoir
reduced irritation and did not interfere with testosterone
absorption. Ointment formulations reduce testosterone absorption.
Gastrointestinal side effects have included nausea and vomiting.
Testosterone is involved in termination of linear bone growth by
closure of the epiphyseal growth centers. Appropriate monitoring of
bone age is recommended during testosterone use in healthy males
with delayed puberty.
Musculoskeletal side effects have included myalgia and pain.
Hematologic side effects have included alteration in clotting
factors II, V, VII and X and polycythemia due to increased red cell
production. Anemia has also been reported.
Hypersensitivity side effects have included rash and anaphylactoid
Local side effects have included inflammation and pain at injection
or dermal application site.
Nervous system side effects have included altered libido
(increased/decreased), headache (to 5%), anxiety, depression,
generalized paresthesia, or sleep apnea syndrome.
Oncologic side effects have included carcinoma of the prostate,
hepatic neoplasms, and hepatocellular carcinomas.
Respiratory side effects have included reports of potentiation of
sleep apnea, particularly in obese patients or those with chronic
lung disease. There have been rare postmarketing reports of
transient reactions involving urge to cough, coughing fits, and
respiratory distress immediately after the injection of testosterone
enanthate, an oil-based depot preparation.