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 HOME >> API >> Dextromethorphan Hydrobromide

Dextromethorphan Hydrobromide

Chemical Formulas
 
  
Dextromethorphan Hydrobromide
pdf api
C18H25NOHBrH2O 370.32

Synonym:
Morphinan, 3-methoxy-17-methyl-, (9α,13α,14α)-, hydrobromide, monohydrate.
3-Methoxy-17-methyl-9α,13α,14α- morphinan hydrobromide, monohydrate

Identifiers
Cas No : 6700-34-1
ATC code R05DA09
PubChem CID 15978238
DrugBank APRD00655
ChemSpider 13109865 Yes
UNII 7355X3ROTS Yes

Chemical data
Formula C18H25NO
Mol. mass 271.4 g/mol
SMILES eMolecules & PubChem
InChI

Physical data
Melt. point 111 C (232 F)
Pharmacokinetic data
Bioavailability 11%

Molecular Weight: 352.31
Empirical Formula (Hill Notation):
C18H25NO HBr H2O

Properties
Suitability meets USP testing specifications

Storage Temperature
Room temperature

Product Information
This product meets USP specifications (Current through USP 23, 4th Supplement), and is traceable to USP Reference Standard lot I

Preserve in tight containers at room temperature. Do not dry; determine water content titrimetrically at time of use. Use promptly. Discard unused material.

TEST USP 23 SPECIFICATIONS Result
 Infrared absorption spectrum
(197K)
 compares to standard  conforms to USP RS lot I
 Ultraviolet absorption spectrum
100 μg/mL (197U)
absorptivities at 278 nm, calculated on the anhydrous basis, differ by not more
than 3%
conforms to USP RS lot I
 Identification C when dissolved 1 in 200, acidified with nitric acid, the addition of silver nitrate causes a yellowish white precipitate to form. passes
 Specific rotation, [α]325 180 mg/10 ml solution in dioxane (781) specific rotation at 325 nm, calculated on the anhydrous basis, does not differ from standard by more than 1.0% passes
pH 1 in 100 solution (791) between 5.2 and 6.5 6.5
 Water, Method I (921) between 3.5% and 5.5% 4.8%
 Residue on ignition (281) not more than 0.1% passes
 Limit of N,N-dimethylaniline 0.001% passes
 Phenolic compounds no blue-green color develops passes
 Assay - high pressure liquid
 chromatography (621)
not less than 98.0% and
not more than 102.0%
101.8%


*** SAMPLE AVAILABLE
Information Associated with Product :  

Dosage
Uses
Side Effects
Pharmacology


                          
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trade basketNote: These API/ chemicals are designated as those that are used in the manufacture of the controlled substances and are important to the manufacture of the substances. For any (Control Substance) products Import and Export *** subjected to your country government laws /control substance ACT.
Note /Government Notification: These chemicals are designated as those that are used in the manufacture of the controlled substances and are important to the manufacture of the substances. For any (Control Substance) products Import and Export *** subjected to your country government laws /control substance ACT.
Information:  The information on this web page is provided to help you to work safely, but it is intended to be an overview of hazards, not a replacement for a full Material Safety Data Sheet (MSDS). MSDS forms can be downloaded from the web sites of many chemical suppliers. ,also that the information on the PTCL Safety web site, where this page was hosted, has been copied onto many other sites, often without permission. If you have any doubts about the veracity of the information that you are viewing, or have any queries, please check the URL that your web browser displays for this page. If the URL begins "www.tajapi.com" the page is maintained by the Safety Officer in Physical Chemistry at Oxford University. If not, this page is a copy made by some other person and we have no responsibility for it.
The Controlled Substances Act (CSA) was enacted into law by the Congress of the United States as Title II of the Comprehensive Drug Abuse Prevention and Control Act of 1970.[1] The CSA is the federal U.S. drug policy under which the manufacture, importation, possession, use and distribution of certain substances is regulated. The Act also served as the national implementing legislation for the Single Convention on Narcotic Drugs
 

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