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HOME >> Pharmaceuticals API List 1 >> Pharmaceuticals API List 2 >> Losartan Potassium >> Drug Description

Losartan Potassium CAS Registry Number 124750-99-8

DRUG DESCRIPTION
Losartan Potassium CAS Registry Number 124750-99-8

Losartan Potassium is an angiostein II receptor (type AT1)antagonist. Losartan and its principle active metabolite block the vasoconstrictor and aldosterone secreting effects of angiostein II by selectively blocking the binding of angiostein II to AT1.

The drug is used for treating High blood pressure and preventing progression of kidney diseases in patients suffering from type 2 diabetes.

The drug acts by preventing the action of a hormone called angiotensin II in the human body. Angiotensin II generally acts on special receptors in the body, with two major results. One, it narrows the peripheral blood vessels , and two, it stimulates the production of hormone aldosterone, another hormone in the body. Aldosterone hormone, causes salt and water to be retained by the kidneys, there by increasing the volume of fluid in the blood vessels. Losartan blocks the receptors that angiotensin II acts on, and so prevents its actions.

Treatment of hypertension; nephropathy in type 2 diabetic patients; reduce risk of stroke in patients with hypertension and left ventricular hypertrophy.

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Losartan Potassium

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