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SIDE EFFECTS
Lacidipine CAS No 103890-78-4
In the treatment of hypertension, some patients may go off control while
still on the drugs. This occurs especially with sympathetic inhibitors and
vasodilators. Lacidipine, a new calcium antagonist acts principally by
vasodilatation. After a wash out period, patients with mild to moderate
hypertension received 4 mg of Lacidipine for two weeks.
After evaluation at two weeks, those uncontrolled received 6 mg of
Lacidipine, while those controlled continued with 4 mg of Lacidipine for
another two weeks. By the next evaluation, while patients continued whatever
doses they were on, any one who had gone off control had 25 mg of
Hydrochlorothiazide added. They were evaluated finally after another two
weeks. It was found in this study that 91.3% (21/23) were controlled by the
end with only Lacidipine either in 4 mg or 6 mg doses. Another 8.7% (2/23)
initially controlled on Lacidipine went off control while still on the drug,
and were eventually controlled by adding Hydrochlorothiazide.
Some transient side effects not warranting discontinuation were encountered.
It is concluded that Lacidipine is effective as monotherapy in mildly to
moderately hypertensive Nigerian Africans; with good tolerance and safety
profile. Where transient control is encountered, addition of a diuretic
could be beneficial.
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