|
|
DRUG DESCRIPTION
Moxifloxacin HCl CAS No.: 186826-86-8
Moxifloxacin Hydrochlorideis a synthetic broad spectrum antibacterial
agent and is available as Tablets for oral administration and as I.V. for
intravenous administration. Moxifloxacin, a fluoroquinolone, is available as
the monohydrochloride salt of
1-cyclopropyl-7-[(S,S)-2,8-diazabicyclo[4.3.0]non-8-yl]-6-fluoro-8-methoxy-1,4-dihydro-4-oxo-3
quinoline carboxylic acid. It is a slightly yellow to yellow crystalline
substance with a molecular weight of 437.9.
The inactive ingredients are microcrystalline cellulose, lactose
monohydrate, croscarmellose sodium, magnesium stearate, hypromellose,
titanium dioxide, polyethylene glycol and ferric oxide.
Moxifloxacin Hydrochlorideis I.V. is available in ready-to-use 250 mL
latex-free flexibags as a sterile, preservative free, 0.8% sodium chloride
aqueous solution of moxifloxacin hydrochloride (containing 400 mg
moxifloxacin) with pH ranging from 4.1 to 4.6. The appearance of the
intravenous solution is yellow. The color does not affect, nor is it
indicative of, product stability. The inactive ingredients are sodium
chloride, USP, Water for Injection, USP, and may include hydrochloric acid
and/or sodium hydroxide for pH adjustment. I.V. contains approximately 34.2
mEq (787 mg) of sodium in 250 mL.
Moxifloxacin is a quinolone/fluoroquinolone antibiotic. Moxifloxacin is
bactericidal and its mode of action depends on blocking of bacterial DNA
replication by binding itself to an enzyme called DNA gyrase, which allows
the untwisting required to replicate one DNA double helix into two. Notably
the drug has 100 times higher affinity for bacterial DNA gyrase than for
mammalian. Moxifloxacin is a broad-spectrum antibiotic that is active
against both Gram-positive and Gram-negative bacteria. For the treatment of
bacterial conjunctivitis caused by susceptible strains
|
©
2004 - 2009
Taj Pharmaceuticals Limited
. All rights reserved
India