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Phenylpropanolamine

CAS number 14838-15-4
                             

Identifiers

Systematic (IUPAC) name (1R,2S)-2-amino-1-phenyl-propan-1-ol

Identifiers

CAS number 14838-15-4
ATC code R01BA01
PubChem 26934
DrugBank APRD00457
ChemSpider 25082

Chemical data

Formula C9H13NO
Mol. mass 151.206 g/mol
Pharmacokinetic data
Half life 2.1 to 3.4 hours.
Therapeutic considerations
Routes Oral

Phenylpropanolamineis a drug ingredient of the phenethylamine family used as a decongestantin prescription and nonprescription (over the counter) cough and cold, and sinus remedies, and some combination allergy medications. It is also present in an appetite suppressant.

Phenylpropanolamine (PPA) is used to treat nasal congestion associated with the common cold, allergies, hay fever, or other respiratory illnesses (e.g., rhinitis, sinusitis). It has also been used as a nonprescription diet-aid for weight loss.

The Food and Drug Administration (FDA) is taking steps to remove phenylpropanolamine (PPA) from all drug products and has requested that all drug companies discontinue marketing products containing PPA. In addition, FDA has issued a public health advisory concerning phenylpropanolamine.

This drug is an ingredient that was used in many over-the-counter (OTC) and prescription cough and cold medications as a decongestant and in OTC weight loss products.

In response to the request made by FDA in November 2000, many companies have voluntarily reformulated and are continuing to reformulate their products to exclude PPA while FDA proceeds with the regulatory process necessary to remove PPA from the market.

Use caution when driving, operating machinery, or performing other hazardous activities. Phenylpropanolamine may cause dizziness or drowsiness. If you experience dizziness or drowsiness, avoid these activities. Never take this medication in larger doses or more often than is recommended. Too much phenylpropanolamine could be very harmful.

Before taking this medication, tell your doctor if you have

* high blood pressure;
* any type of heart disease, hardening of the arteries, or irregular heartbeat;
* thyroid problems;
* diabetes;
* glaucoma or increased pressure in your eye;
* an enlarged prostate or difficulty urinating; or
* liver or kidney disease.

Use caution when driving, operating machinery, or performing other hazardous activities. Phenylpropanolamine may cause dizziness or drowsiness.

If you experience dizziness or drowsiness, avoid these activities. Never take this medication in larger doses or more often than is recommended. Too much phenylpropanolamine could be very harmful.

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