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Naratriptan

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HOME >> Pharmaceuticals API List 2 >> Naratriptan >> Drug Description

Naratriptan CAS number 121679-13-8

DRUG DESCRIPTION
Naratriptan CAS number 121679-13-8

Naratriptan is used to treat the symptoms of migraine headaches (severe, throbbing headaches that sometimes are accompanied by nausea and sensitivity to sound or light). Naratriptan is in a class of medications called selective serotonin receptor agonists. It works by narrowing blood vessels in the brain, stopping pain signals from being sent to the brain, and stopping the release of certain natural substances that cause pain, nausea, and other symptoms of migraine. Naratriptan does not prevent migraine attacks.

Naratriptan hydrochloride is a white to pale yellow powder that is readily soluble in water. Each  Tablet for oral administration contains 1.11 or 2.78 mg of naratriptan hydrochloride equivalent to 1 or 2.5 mg of naratriptan, respectively. Each tablet also contains the inactive ingredients croscarmellose sodium; hypromellose; lactose; magnesium stearate; microcrystalline cellulose; triacetin; and titanium dioxide, iron oxide yellow (2.5-mg tablet only), and indigo carmine aluminum lake (FD&C Blue No. 2) (2.5-mg tablet only) for coloring.

It is thought that the widening of blood vessels in the brain causes the pain associated with migraine. The blood vessels widen on release of a chemical called serotonin. Naratriptan works by binding to receptors in the brain to prevent serotonin from binding. This causes the blood vessels to narrow and relieves the pain felt during a migraine.

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Naratriptan

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